PK.

Software · Desktop app

Codon Atlas

Predicts the genetic code from a genome sequence and searches it for alternative decoding. It aligns a six-frame translation to Pfam protein families and, for each of the 64 codons, works out which amino acid the conserved positions it lands on expect (the Codetta method), then flags reassigned codons, stop codons inside conserved domains, and the tRNAs that could read each codon, lists every affected site in the genes, and exports the protein databases needed to test a reassignment by proteomics.

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Codon Atlas screenshot of the Mycoplasma genitalium G37 genome: the codon wheel with UGA read as tryptophan highlighted, and the decoding probabilities for UGA
The public Mycoplasma genitalium G37 genome: UGA is called as tryptophan from 308 aligned Pfam positions, its known genetic code.

What it does

Where it runs

A desktop app. Pfam is downloaded once; after that genomes are analysed on your computer (about a minute for a bacterial genome).

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